Refined sugar contains very little nutritional value, but packs a huge calorie punch. If you have a sweet tooth and want to give up refined sugar, you have a plethora of natural, healthy substitutes to choose from. When looking for sugar substitutes, make sure that you go natural rather than synthetic. While artificial sweeteners may contain fewer calories, they have been linked to cancers and other physical ailments. With these natural sweeteners, you can have your cake, and eat it too!